Obesity-induced nucleosome release predicts poor cardio-metabolic health

Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity

White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely a...

Salt-induced release of DNA from nucleosome core particles.

At elevated salt concentrations, the structure of chromatin is destabilized. This paper is concerned with the processes by which DNA is released from nucleosome core particles in free, uncomplexed form. Our experiments indicate that the DNA release reaction has distinctly different characteristics below and above approximately 0.75 M NaCl. Below this concentration of salt, release of the histon...

which one is more important, obesity or cardio metabolic risk factors?

Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study.

OBJECTIVES To determine the age of significant divergence in body mass index (BMI) and waist circumference in adults with and without the metabolic syndrome, and to provide age- and sex-specific childhood values that predict adult metabolic syndrome. STUDY DESIGN Part 1 of this study is a retrospective cohort study of 92 men and 59 women (mean age, 51 years) who had metabolic syndrome and 154...

Sleep and Cardio-Metabolic Disease

PURPOSE OF REVIEW This review summarises and discusses the epidemiological evidence suggesting a causal relationship between sleep duration and cardio-metabolic risk and outcomes in population. RECENT FINDINGS Sleep duration is affected by a variety of cultural, social, psychological, behavioural, pathophysiological and environmental influences. Changes in modern society-like longer working h...